Cellular Dynamics in Cancer
A multidisciplinary approach to future cancer therapies
CRC1709 combines basic, translational, and clinical research to uncover cancer cell plasticity in myeloid malignancies. Using advanced technologies and AI-driven data integration, we aim to transform how these cancers are understood, diagnosed, and treated.
Research
Understanding cellular plasticity from multiple angles
CRC1709 is structured into research areas focusing on cell-intrinsic mechanisms, cell-extrinsic influences, and shared technology platforms.
Cell Intrinsic Factors (Area A)
We investigate the molecular mechanisms inside cancer cells, including epigenetics, metabolism, RNA modification, and lineage identity, that drive cellular plasticity in myeloid malignancies.
Cell Extrinsic Factors (Area B)
We explore how external influences such as inflammation, therapy stress, microenvironmental cues, and immune interactions shape malignant cell states and enable resistance.
Core Projects
Our technology platforms integrate single-cell multi-omics, proteomics, AI-driven data analysis, and patient-derived xenograft models, enabling deep insights across all research areas.
Publications
Mapping cancer cell states across disease evolution
We follow leukemic stem and progenitor cells over time, from pre-malignant conditions to relapse, to understand how they switch between dormant, resistant and proliferative states. These dynamic trajectories reveal vulnerabilities that may guide innovative therapeutic strategies.
Team & Partner
Our consortium of scientists, clinicians, and partners
More than 30 principal investigators from Heidelberg, Mannheim, Berlin, Munich, Frankfurt, and Langen collaborate within CRC1709. Our consortium combines basic science and clinical expertise with cutting-edge technologies to accelerate the translation of plasticity research into therapeutic innovation.
News
Latest News Articles
Beyond the Seminar: CRC1709 launches a new networking format for Early Career Researchers
On July 27, 2026, CRC1709 was pleased to welcome Prof.…
CRC1709 welcomes Prof. Brian Huntly as invited speaker
As part of the CRC1709 Invited Speaker Series, we are…
New Publication in Blood: Single-cell MRD reveals AML patients benefiting from CXCR4 inhibition
CRC 1709 postdoctoral researcher Enise Ceran is the first author…
Events
Advancing cancer research through collaborative events
CRC1709 hosts seminars, workshops, and symposia that bring together experts from basic science, clinical research, computational biology, and translational oncology. These events foster interdisciplinary exchange, highlight emerging insights into cancer cell plasticity, and support the development of innovative therapeutic approaches.
By decoding the plasticity of myeloid malignancies, we aim to fundamentally change how we understand and treat aggressive blood cancers.
Prof. Carsten Müller-Tidow
Spokesperson, CRC1709—Cellular Plasticity in Myeloid Malignancies
