Summary
Using innovative techniques, including dynamic differentiation and fate tracking, 3D co-culture models, and clone tracing, project B10 will analyze the role of DDX41 in activation of cancer cell innate immune responses and how DDX41-mediated cGAS-STING signaling contributes to hematopoietic stem and progenitor cell plasticity and leukemogenesis. This project highlights how cell intrinsic properties (e.g. germline DDX41 mutations) affect innate immune response that may drive leukemogenesis via increased inflammation.
Lead Investigator
Axel Roers, Prof. Dr. med.
Department of Immunology, Heidelberg University Hospital
Lead Investigator
Simone Feurstein, Dr. med.
Department of Hematology, Oncology and Rheumatology, Heidelberg University Hospital
Team:
Cell-Extrinsic Factors (Area B)
Our consortium of scientists, clinicians and partners
Axel Roers, Prof. Dr. med.
Principal Investigator, Scientific Manager, Steering Committee
Emilija Marinkovic, Ph.D.
Postdoc
Keyi Ao
PhD student
Simone Feurstein, Dr. med.
Principal Investigator
