Summary
Project B01 will analyze variability of AML blasts as determinants of response to venetoclax and azacytidine treatment. Advanced multiomics scRNA-Seq and generative AI- based image analysis will be applied to paired primary samples (diagnosis/relapse) to integrate cellular morphology with molecular analyses in order to predict treatment outcomes and to identify novel VEN/AZA response biomarkers.
PRINCIPAL Investigator
Jakob Nikolas Kather, Prof. Dr. med., M.Sc.
Department of Medical Oncology (NCT-HD), Heidelberg University Hospital
PRINCIPAL Investigator
Maike Janssen, Dr. med.
Department of Hematology, Oncology and Rheumatology, University Hospital Heidelberg
Team:
Cell-Extrinsic Factors (Area B)
Our consortium of scientists, clinicians and partners
Jakob Nikolas Kather, Prof. Dr. med., M.Sc.
Principal Investigator
Jiefu Zhu
PhD student
Julia Herzberg
PhD student
Maike Janssen, Dr. med.
Junior PI Representative, Principal Investigator, Steering Committee
