Summary
Using nanopore sequencing of single native RNA molecules from primary samples project A01 will comprehensively identify AML- associated epitranscriptomic changes in rRNA and its functional consequences for cellular plasticity. Regulators that induce specific rRNA modifications patterns, such as snoRNAs, will be characterized via focused CRISPR screens to identify therapeutic vulnerabilities.
principal Investigator
Carsten Müller-Tidow, Prof. Dr. med.
Department of Hematology, Oncology and Rheumatology
Team:
Cell-Intrinsic Factors (Area A)
Our consortium of scientists, clinicians and partners
Carsten Müller-Tidow, Prof. Dr. med.
Principal Investigator, Spokesperson
Viral Shah, Dr. rer. nat.
Postdoc
