Summary
Project B07 will apply single-cell and imaging technologies to characterize BM niche plasticity in AML during the course of the disease and treatment. Identified candidate genes will be functionally investigated by treating AML blasts with niche-targeting drugs acting against niche-induced LSC plasticity. These niche remodeling drugs will be subsequently combined with LSC- targeting drugs and their synergism will be assessed in vivo.
Lead Investigator
Caroline Pabst, PD Dr. med.
Department of Hematology, Oncology and Rheumatology, University Hospital Heidelberg
Lead Investigator
Judith Zaugg, Prof. Dr. rer. nat.
Computational Biology, European Molecular Biology Laboratory (EMBL), Heidelberg
Team:
Cell-Extrinsic Factors (Area B)
Our consortium of scientists, clinicians and partners
Bahar Orhan
PhD student
Caroline Pabst, PD Dr. med.
Principal Investigator
Judith Zaugg, Prof. Dr. rer. nat.
Principal Investigator, Scientific Manager, Steering Committee
