B11: Deciphering and therapeutically exploiting immunerelated cellular plasticity during allogeneic stem celltransplantation in myeloid malignancies

Project B11 aims to systematically study the role of donor-host interactions in mediating therapy outcome in MNs. In particular, by using primary samples from initial diagnosis, remission, pre-alloSCT and post-alloSCT and single cell multiomics B11 will focus on systematically dissecting the role of cellular plasticity that is observed in leukemic cells and the immune system as a direct consequence of cellular interactions between donor and host cells. B11 will identify molecular, cellular and immunological candidate pathways and mechanisms that mediate effective GvL or cause GvHD, and will assess whether blockade or boost of specific immune pathways can be used to improve the balance between positive GvL and adverse effects.