B10: Cellular plasticity driven by innate immune activation in DDX41-mediated myeloid malignancies

Using innovative techniques, including dynamic differentiation and fate tracking, 3D co-culture models, and clone tracing, project B10 will analyze the role of DDX41 in activation of cancer cell innate immune responses and how DDX41-mediated cGAS-STING signaling contributes to hematopoietic stem and progenitor cell plasticity and leukemogenesis. This project highlights how cell intrinsic properties (e.g. germline DDX41 mutations) affect innate immune response that may drive leukemogenesis via increased inflammation.