Summary
In project A05 single cell multi-omics will be applied to analyze triplet primary AML samples (diagnosis, remission, relapse) to identify reversible plastic LSC states and identify non-genetic molecular drivers of dormancy and thus resistance and relapse. Furthermore, A05 will elaborate metabolic LSC states along the AML therapy course using advanced cellular barcoding technologies to trace plasticity of distinct LSC states.
Lead Investigator
Prof. Dr. Andreas Trumpp
HI-STEM gGmbH, Heidelberg Institute for Stem Cell Technology and Experimental Medicine, Heidelberg
Team:
Cell-Intrinsic Factors (Area A)
Our consortium of scientists, clinicians and partners
Dr. Patrick Stelmach
Postdoc
Prof. Dr. Andreas Trumpp
Deputy Spokesperson, Principal Investigator
