A01: Functions of the dynamic ribosomal epitranscriptome in shaping myeloid plasticity

Using nanopore sequencing of single native RNA molecules from primary samples project A01 will comprehensively identify AML- associated epitranscriptomic changes in rRNA and its functional consequences for cellular plasticity. Regulators that induce specific rRNA modifications patterns, such as snoRNAs, will be characterized via focused CRISPR screens to identify therapeutic vulnerabilities.